计算机应用 ›› 2005, Vol. 25 ›› Issue (09): 2169-2170.DOI: 10.3724/SP.J.1087.2005.02169

• 典型应用 • 上一篇    下一篇

含先验信息的学习机在生物序列分析中的应用

刘颖1,林元烈2,覃征1,3   

  1. 1.清华大学软件学院; 2.清华大学数学科学系; 3.清华大学计算机科学与技术系
  • 出版日期:2005-09-01 发布日期:2011-04-11
  • 基金资助:

    国家自然科学基金资助项目(10371063);;国家科技攻关项目(2004BA711A21);;国家863计划资助项目(2003AA412020)

Application of prior-knowledge-bearing learning machine in biological sequence analysis

LIU Ying1,LIN Yuan-lie2,QIN Zheng1,3   

  1. 1.School of Software,Tsinghua University,Beijing 100084,China;2.Department of Mathematical Sciences,Tsinghua University,Beijing 100084,China;3.Department of Computer Science and Technology,Tsinghua University,Beijing 100084,China
  • Online:2005-09-01 Published:2011-04-11

摘要: 生物序列分析是机器学习和数据挖掘技术一个重要的应用领域。它的特别之处在于,很多有领域背景的先验知识可以在分析过程中得到利用,从而改善分析的效果。在对蛋白质的乙酰化修饰的预测过程中,通过合理地利用先验信息,改进模式提取方法,能够显著地提高支持向量机模型的预测性能。

关键词: 先验信息, 生物序列分析, 机器学习, 支持向量机

Abstract: Biological sequence analysis is an important application domain of data mining technology.Its particularity lies in that a great deal of prior knowledge can be utilized to improve the learning process.In the research of the protein modification of N-acetylation,by properly using prior knowledge and upgrading the pattern extraction method,improvement in performance of the SVM model was achieved.

Key words: prior knowledge, biological sequence analysis, machine learning, support vector machine(SVM)

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