Prediction of Parkinson’s disease based on multi-task regression of model filtering

doi:10.11772/j.issn.1001-9081.2018041329

Journal of Computer Applications ›› 2018, Vol. 38 ›› Issue (11): 3221-3224.DOI: 10.11772/j.issn.1001-9081.2018041329

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Prediction of Parkinson’s disease based on multi-task regression of model filtering

LIU Feng¹, JI Wei¹, LI Yun²

1. College of Telecommunications and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing Jiangsu 210003, China;
2. College of Computer Science and Technology, Nanjing University of Posts and Telecommunications, Nanjing Jiangsu 210023, China

Received:2018-04-30 Revised:2018-06-21 Online:2018-11-10 Published:2018-11-10
Supported by:
This work is partially supported by the National Natural Science Foundation of China (61603197,61772284,41571389), the Nangjing University of Posts and Telecommunications Fund (NY215104).

基于模型过滤的多任务回归在帕金森症预测中的应用

刘峰¹, 季薇¹, 李云²

1. 南京邮电大学通信与信息工程学院, 南京 210003;
2. 南京邮电大学计算机学院, 南京 210023

通讯作者: 刘峰
作者简介:刘峰(1990-),男,江苏泰州人,硕士研究生,主要研究方向:机器学习、数据挖掘;季薇(1979-),女,江苏淮安人,副教授,博士,主要研究方向:信号处理、机器学习;李云(1974-),安徽芜湖人,教授,博士,CCF会员,主要研究方向:机器学习、数据挖掘、模式识别。
基金资助:
国家自然科学基金资助项目（61603197，61772284，41571389）；南京邮电大学科研基金资助项目（NY215104）。

Abstract

Abstract: The traditional speech-based Parkinson's Disease (PD) prediction method is to predict the motor Unified Parkinson's Disease Rating Scale (motor-UPDRS) and the total Unified Parkinson's Disease Rating Scale (total-UPDRS) respectively. In order to solve the problem that the traditional method could not use the shared information between tasks and the poor prediction performance in the process of single task prediction, a multi-task regression method based on model filtering was proposed to predict the motor-UPDRS and total-UPDRS of Parkinson's disease patients. Firstly, considering the different effects of the subtask speech features on the predicted motor-UPDRS and total-UPDRS, an L1 regularization term was added for feature selection. Secondly, according to different Parkinson's patient objects distributed in different domains, a filtering mechanism was added to improve the prediction accuracy. In the simulation experiments of remote Parkinson data set, the Mean Absolute Error (MAE) of motor-UPDRS is 67.2% higher than that of the Least Squares (LS) method. Compared with the Classification And Regression Tree (CART) in the single task, the motor value increased by 64% and the total value increased by 78.4%. The results of experiment show that multi-task regression based on model filtering is superior to the single task regression algorithm for UPDRS prediction.

Key words: Parkinson's Disease (PD), speech, multi-task regression, model filtering, feature selection, unified Parkinson's disease rating scale

摘要： 传统基于语音的帕金森症（PD）病情预测方法则是分别预测运动症状评分（motor-UPDRS）和总体症状评分（total-UPDRS）。为解决在单任务预测过程中，传统方法无法利用任务之间的共享信息和预测性能不佳的问题，提出了一种基于模型过滤的多任务回归方法来预测帕金森症患者的motor-UPDRS和total-UPDRS。首先，考虑到子任务语音特征对预测motor-UPDRS和total-UPDRS不同的影响，添加L1正则化项进行特征选择；其次，在构建模型的同时，根据不同帕金森患者对象分布在不同的域，添加了过滤机制，来提高预测精度。在远程帕金森数据集仿真实验中，基于模型过滤的多任务回归方法在预测UPDRS时，较单任务条件下最小二乘法（LS）模型预测motor值准确度提高了67.2%，预测total值则提高了83.3%；相比单任务条件下决策回归树（CART）模型预测motor值提高了64%，预测total值则提高了78.4%。实验结果表明，基于模型过滤的多任务回归算法对UPDRS预测要优于单任务回归算法。

关键词: 帕金森症, 语音, 多任务回归, 模型过滤, 特征选择, 统一帕金森评定量表

CLC Number:

TP391

LIU Feng, JI Wei, LI Yun. Prediction of Parkinson’s disease based on multi-task regression of model filtering[J]. Journal of Computer Applications, 2018, 38(11): 3221-3224.

刘峰, 季薇, 李云. 基于模型过滤的多任务回归在帕金森症预测中的应用[J]. 计算机应用, 2018, 38(11): 3221-3224.

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Prediction of Parkinson’s disease based on multi-task regression of model filtering

基于模型过滤的多任务回归在帕金森症预测中的应用

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