In recent years, many studies that use human skeleton graph for video anomaly detection only consider the directly connected nodes when describing the strength of human skeleton connection, focusing on a small moving region and ignoring local features, so it is still very difficult to accurately detect pedestrian abnormal events. To solve the above problems, a video pedestrian anomaly detection method called PAD-SGMA (video Pedestrian Anomaly Detection method based on Skeleton Graph and Mixed Attention) was proposed. The association between skeleton points was extended, the root node was connected with the nodes that were not directly connected, and the human skeleton graph was divided to obtain the local features of the human skeleton. In the graph convolution module, static global skeleton, local region skeleton and attention-based adjacency matrix were used to capture the hierarchical representation. Secondly, a new convolutional network of spatio-temporal channel mixed attention was proposed, in which a mixed attention module was added to focus on spatial and channel relationships, to help the model enhance distinguishing features and pay different degrees of attention to different joints. In order to verify the proposed model, experiments were carried out on a large-scale open standard dataset ShanghaiTech Campus dataset, and the experimental results showed that the AUC(Area Under Curve) of PAD-SGMA was increased by 0.018 compared with GEPC (Graph Embedded Pose Clustering).