A new algorithm was proposed to meet the instantaneous response requirements of the Boolean operation between large-scale mesh models in the product design. Discrete sampling was performed on mesh models to obtain the ray-segment point clound model and the three-dimensional Boolean operation among triangular mesh was then converted into one-dimensional one among ray segments; the intersection points could be accurately solved and interpolated around the overlapped regions of mesh models, so the Boolean operation was significantly speeded and the design efficiency of products of complex topology was greatly improved in turn. The point cloud model obtained by the proposed algorithm could be rendered with the same effect as that by the triangular mesh model. The proposed method can be adopted in engineering applications.