To address the problem that traditional flight operation performance evaluation methods are highly subjective, analyze parameters one-sidedly, and cannot be quantified comprehensively and objectively, a Multi-dimensional Feature Analysis based Gradient Boosting Regression Tree (MFA-GBRT) method was proposed. In the method, time-domain and trend features of Quick Access Recorder (QAR) data were extracted, and an improved Gradient Boosting Regression Tree (GBRT) was combined with a threshold cumulative importance filtering mechanism, an evaluation index system covering “attitude control-power management-environmental response” and a performance level evaluation model were constructed. Experimental results on simulator and flight base data show that the average evaluation accuracy of the proposed method reaches 87.83%, which is 10.78%, 6.06% and 3.55% higher than those of the existing methods Long Short-Term Memory-Deep Neural Network (LSTM-DNN), curve similarity method and wavelet analysis, respectively. Cross-scenario validation show that the method has adaptability over 95% (high adaptability) in three different flight scenarios. It can be seen that the method realizes full-process objective quantitative evaluation of the flight process and provides a scientific scheme with engineering practicability for flight operation performance evaluation.