Concerning the disadvantages such as the complexity of the system structure, low compatibility and expansibility, time consuming in development and deployment, low security and anti-interference in the smart lighting system based on Power Line Communication (PLC), a new smart lighting system based on IPv6 over Low power Wireless Personal Area Network (6LoWPAN) was proposed in this paper. An example of implementing 6LoWPAN in smart lighting system by replacing PLC was presented, the PLC nodes were replaced by 6LoWPAN nodes, the central controller was replaced by border router, and the Constrained Application Protocol (CoAP) and Internet Protocol for Smart Objects (IPSO) application framework was applied in the application layer. Compared with the smart lighting system based on PLC, the new smart lighting system with 6LoWPAN technology is simpler in system architecture, it has higher compatibility and expansibility, the development and deployment time is reduced more than 50%, the network security and anti-interference is better.