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基于概率稀疏自注意力神经网络的重性抑郁疾患诊断

秦璟1秦志光1李发礼2彭悦恒2   

  1. 1. 电子科技大学 信息与软件工程学院 2. 电子科技大学 生命科学与技术学院
  • 收稿日期:2023-10-10 修回日期:2024-01-05 发布日期:2024-01-31 出版日期:2024-01-31
  • 通讯作者: 秦璟
  • 作者简介:秦璟(1994—),男,四川成都人,博士研究生,CCF会员,主要研究方向:医学图像与信号处理;秦志光(1956—),男,四川成都人,教授,博士,CCF会员,主要研究方向:计算机开放系统与网络安全性、信息系统安全、智能交通系统、电子商务;李发礼(1990—),男,山东临沂人,副研究员,博士,主要研究方向:脑神经机制、脑网络分析、脑机交互;彭悦恒(1993—),男,四川成都人,博士研究生,主要研究方向:脑神经机制、脑网络分析、脑机交互。
  • 基金资助:
    国家自然科学基金资助项目(62027827)

Diagnosis of major depressive disorder based on probabilistic sparse self-attention neural network

QIN Jing1,2, QIN Zhiguang1, LI Fali2, PENG Yueheng2   

  1. 1. School of Information and Software Engineering, University of Electronic Science and Technology of China 2. School of Life Science and Technology, University of Electronic Science and Technology of China
  • Received:2023-10-10 Revised:2024-01-05 Online:2024-01-31 Published:2024-01-31
  • About author:QIN Jing, born in 1994, Ph. D. His research interests include medical image and signal processing. QIN Zhiguang, born in 1956, Ph. D., professor. His research interests include computer open systems and network security, information system security, intelligent transportation systems, e-commerce. Li Fali, born in 1990, Ph. D., associate research fellow. His research interessts include brain neural mechanisms, brain network analysis, brain-computer interaction. PENG Yueheng, born in 1993, Ph. D. His research interests include brain neural mechanisms, brain network analysis, brain-computer interaction.
  • Supported by:
    National Natural Science Foundation of China (62027827)

摘要: 抑郁症的诊断主要依赖于医师的咨询和量表评估等主观方法,可能导致误诊。与其他生理测量工具(如计算机断层扫描(CT)和功能性磁共振成像(fMRI))相比,脑电图(EEG)具有高时间分辨率、低成本、易于设置和无创技术等优点,因此可以用作精神障碍,包括抑郁症的定量测量工具。深度学习算法目前在EEG信号上有多种运用,其中就包括抑郁症的诊断和分类。EGG信号在通过自注意力机制处理时有大量的冗余部分,因此,提出一种基于概率稀疏自注意力机制的卷积神经网络(PSANet)。首先,根据采样因数在自注意力机制中选取了少量最关键的注意力点,在运用自注意力机制的同时克服了它计算成本高的缺点,使它可以在脑电长序列数据上应用;同时将脑电图与患者的生理量表进行嵌合,从而进行多维度诊断。在一个包含抑郁症患者和健康对照组的数据集上进行实验评估,实验结果表明,PSANet表现出较高的分类准确性,参数量也低于对比方法。

关键词: 抑郁症诊断, 脑电图, 深度学习, 自注意力机制, 卷积神经网络

Abstract: The diagnosis of major depressive disorder predominantly relies on subjective methods, including physician consultations and scale assessments, which may lead to misdiagnosis. In comparison to other physiological measurement tools, such as CT (Computed Tomography) and fMRI (functional Magnetic Resonance Imaging), EEG (ElectroEncephaloGram) offers advantages such as high temporal resolution, low cost, ease of setup, and non-invasiveness, making it a potential quantitative measurement tool for psychiatric disorders, including depression. Recently, deep learning algorithms have been diversely applied to EEG signals, notably in the diagnosis and classification of depression. Due to significant redundancy is observed when processing EEG signals through a self-attention mechanism, a convolutional neural network leveraging a Probabilistic sparse Self-Attention mechanism (PSANet) was proposed. Firstly, a limited number of pivotal attention points were chosen in the self-attention mechanism based on the sampling factor, addressing the high computational cost and facilitating its application to extensive EEG data sequences; concurrently, EEG data was amalgamated with patients' physiological scales for a comprehensive diagnosis. Experiments were executed on a dataset encompassing both depression patients and a healthy control group. Experimental results show that PSANet exhibits superior classification accuracy and a reduced parameter count relative to alternative methodologies.

Key words: depression disorder diagnosis, ElectroEncephaloGraphy (EEG), deep learning, self-attention mechanism, convolutional neural network

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